The Endo Exchange: MCAS, Histamine Intolerance & Endometriosis
- Friday, July 31, 2026
- Virtual
- 2:00 PM – 3:00 PM ET
- Register (Free)
EPISODE #9:
When Endometriosis and the Immune System Intersect
Endometriosis affects far more than the pelvis. For some patients, it may fuel a cascade of systemic inflammation that contributes to mast cell activation syndrome, histamine intolerance, food sensitivities, and widespread immune dysfunction. These overlapping conditions are still being better understood, leaving many patients searching for answers across multiple specialists.
In this episode of The Endo Exchange, we bring together three unique perspectives to explore this critical overlap. Dr. Karli Provost Goldstein, an ESSE Care surgeon specializing in endometriosis excision, Dr. Laura Gouge, a naturopathic doctor specializing in MCAS and endometriosis, and Haley Argiento, a patient whose stage IV endometriosis excision surgery proved to be a pivotal turning point in her seven-year experience with severe mast cell activation syndrome.
Together, we will discuss the role expert excision surgery may play as part of comprehensive care for some patients with overlapping conditions, how endometriosis-driven inflammation may contribute to immune reactivity, and what meaningful recovery can look like when the right providers finally connect the dots.
This episode is for you if:
- You are living with endometriosis and wondering whether MCAS or histamine intolerance may also be contributing to your symptoms
- You experience unexplained food sensitivities, anaphylactic reactions, or systemic inflammation alongside your endo symptoms
- You have been dismissed by multiple specialists and are searching for answers about your overlapping conditions
- You are a healthcare provider looking to better understand the connection between mast cell activation, histamine, and endometriosis
- You want to learn how excision surgery may support immune function as part of a broader care plan
- You are navigating a complex, multi-system chronic illness and want to hear a real recovery story
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Featured Speakers
Dr. Goldstein
Endometriosis Excision Surgeon, Founder of ESSE Care. Fellowship-trained, world-leading endometriosis and fertility surgeon known for her precision, compassion, and integrative approach. Learn more.
Dr. Gouge
Naturopathic Doctor and Certified Nutrition Specialist with over a decade of experience treating MCAS, endometriosis, and POTS. She brings her own lived experience with these conditions to her mission of helping patients find lasting solutions. Learn more.
Haley Argiento
Patient advocate navigating stage IV endometriosis and mast cell activation syndrome. After years of searching for answers, she shares her story to help others feel less alone, advocate for themselves, and remember they are more than their diagnoses.
What This Discussion Will Explore
The Endo–MCAS Connection
Mast cells and chronic inflammation may contribute to symptoms both inside and beyond the pelvis, and why understanding this relationship matters.
Histamine &
Hormones
How hormones, histamine, and gut health may influence endometriosis symptoms for some patients.
The Role
of Excision
How expert excision surgery may help reduce inflammation as one part of a patient’s overall care plan.
Collaborative
Care
Why collaboration between excision surgeons, naturopathic doctors, and other specialists can be valuable when caring for complex conditions.